Sodium Hydroxide → HCID 23710092, compound

HRID 982415Notes

Reaction equation

HRID 982415 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH2:13][C:12]([CH3:15])([CH3:14])[CH2:11][C:10]([CH3:17])([CH3:16])[C:9]=2/[CH:18]=[CH:19]/[C@@H:20]2[O:25][C:24](=[O:26])[CH2:23][C@@H:22]([OH:27])[CH2:21]2)=[CH:4][CH:3]=1.[OH-:28].[Na+:29]>C(O)C>[Na+:29].[F:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[CH2:13][C:12]([CH3:14])([CH3:15])[CH2:11][C:10]([CH3:17])([CH3:16])[C:9]=2/[CH:18]=[CH:19]/[CH:20]([OH:28])[CH2:21][CH:22]([OH:27])[CH2:23][C:24]([O-:25])=[O:26])=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 14651086HCID 14651086, compound

Product 1

HCID 23710092HCID 23710092, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a solution of 1.17 g (3.14 mmoles) of the lactone prepared in Step 11, and 21 ml of ethanol was added 3.14 ml of 1N NaOH (3.14 mmoles). After stirring for 30 minutes, the ethanol was removed in vacuo. The residue was redissolved in 50 ml of HPLC grade H2O and extracted twice with hexane. The water layer was freeze-dried to yield a white powder. M.P. 160°-190° C. (dec).

Workup

  1. customthe ethanol was removed in vacuo
  2. dissolutionThe residue was redissolved in 50 ml of HPLC grade H2O
  3. extractionextracted twice with hexane
  4. dry with materialThe water layer was freeze-dried
  5. customto yield a white powder

Sources & evidence

ORD record
ord-5fe4156d4de54394ab0b15f85d889261
Source dataset
uspto-grants-1991_02
Patent number
US04996234

Reaction notes

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