Ethanol → HCID 15718055, compound

Participants

Reaction Steps

A solution of 17.8 g of 2-(3-hydroxyphenoxy)benzoic acid in 250 ml of ethanol and 1 ml of sulfuric acid was heated at reflux for two days. After cooling, the mixture was concentrated in vacuo. The residue was partitioned between ethyl acetate and water. The organic layer was dried and concentrated in vacuo. The resulting residue was purified by high pressure liquid chromatography eluting with a 0-30% ethyl acetate in hexane gradient. The appropriate fractions were combined and concentrated in vacuo to provide 16.78 g of the desired subtitled intermediate as an oil.

Provenance & Evidence