3-Methoxyphenol → HCID 15718075, compound

HRID 982451Notes

Reaction equation

HRID 982451 reaction equation
[CH2:1]([O:3][C:4]([C:6]1[CH:11]=[CH:10][C:9](Br)=[C:8]([C:13]([O:15][CH2:16][CH3:17])=[O:14])[CH:7]=1)=[O:5])[CH3:2].[CH3:18][O:19][C:20]1[CH:21]=[C:22]([OH:26])[CH:23]=[CH:24][CH:25]=1>[Cu]>[CH2:1]([O:3][C:4]([C:6]1[CH:11]=[CH:10][C:9]([O:26][C:22]2[CH:23]=[CH:24][CH:25]=[C:20]([O:19][CH3:18])[CH:21]=2)=[C:8]([C:13]([O:15][CH2:16][CH3:17])=[O:14])[CH:7]=1)=[O:5])[CH3:2]

Participants

4

Reactant 2

HCID 90073-MethoxyphenolHCID 115241874-bromoisophthalic acid diethyl ester

Product 1

HCID 15718075HCID 15718075, compoundYield 41.8%

Reagents, catalysts & solvents 1

HCID 23978CopperCatalyst

Procedure

Following the general procedure of Example 1A, 3.49 g of 4-bromo-1,3-benzenedicarboxylic acid diethyl ester and 1.43 g of 3-methoxyphenol were allowed to react in the presence of powdered copper metal to provide 1.66 g of the desired subtitle intermediate as an oil.

Sources & evidence

ORD record
ord-f4c1280651b64d2b84da5ccc8ffef47c
Source dataset
uspto-grants-1991_02
Patent number
US04996230

Reaction notes

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