Sodium borohydride → HCID 15078335, compound

Participants

Reaction Conditions

Reaction Steps

Sodium borohydride (0.66 g) was added to a suspension of 1-[3-(2-hydroxyethylsulfonyl)-4-propoxy-5-benzyloxyphenyl]-4-(3,4,5-trimethoxyphenyl)butan-1,4-dione (from previous experiment) in ethanol (125 mL), and the mixture was heated at 75° C. for 2 h. The solution was cooled and diluted with dichloromethane. It was then washed with 2.5N HCl (2×) and water, dried, and evaporated to a syrup, Rf 0.11 (hexane-ethyl acetate; 1:1, v/v). This material was used directly in the next experiment without further purification.

Provenance & Evidence