HCID 15078315, compound → HCID 15078317, compound

Participants

Reaction Steps

A solution of trans-2-[3-(2-hydroxyethylsulfonyl)-4-n-propoxy-5-benzyloxyphenyl]-5-(3,4,5-trimethoxyphenyl)tetrahydrofuran (440 mg) in ethyl acetate (6 mL) was hydrogenated over 10% palladium-on-charcoal (120 mg) at 45 psi for 1 h. The catalyst was filtered off and washed with ethyl acetate. The combined filtrates were evaporated to give the title compound: Rf 0.1 (hexane-ethyl acetate; 1:1, v/v); NMR (CDCl3) δ 1.07 (t, CH2CH2CH3), 3.60 (q, SO2CH2), 3.95 (q, SO2CH2CH2), 3.84 (s, OCH3), 3.88 (s, 2 OCH3), 4.11 (t, CH2CH2CH3), 5.13-5.25 (m, H-2 and H-5), 6.61 (s, 2 H, C5ArH), 7.32 and 7.49 (2 d, J=2.0 Hz, C2ArH).

Provenance & Evidence