Acetyl chloride → HCID 11131690, compound

HRID 982512Notes

Reaction equation

HRID 982512 reaction equation
[CH2:1]([N:3]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[CH:5]=[C:4]1[CH3:12])[CH3:2].[C:13](Cl)(=O)[CH3:14]>O>[CH2:1]([N:3]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[C:5]([C:4]([C:5]2[C:6]3[C:11](=[CH:10][CH:9]=[CH:8][CH:7]=3)[N:3]([CH2:1][CH3:2])[C:13]=2[CH3:14])=[CH2:12])=[C:4]1[CH3:12])[CH3:2]

Participants

4

Reactant 2

HCID 6367Acetyl chlorideHCID 1704321H-Indole, 1-ethyl-2-methyl-

Product 1

HCID 11131690HCID 11131690, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A mixture of 1-ethyl-2-methylindole (15.9 g, 0.1 mole) and acetyl chloride (9.4 g, 0.12 mole) was stirred at room temperature for 20 hours. Then, water (100 ml) was added to the reaction mixture and the resulting grains were filtered and dried. The dried product was recrystallized from toluene/methanol. Yield: 13.0 g (77.0%). M.P.:183-185° C. IR (KBr) spectrum was identical to that of the product in Example 1.

Workup

  1. filtrationthe resulting grains were filtered
  2. customdried
  3. customThe dried product was recrystallized from toluene/methanol

Sources & evidence

ORD record
ord-9aef16ff0b1244d6930dfcae28dd6004
Source dataset
uspto-grants-1991_02
Patent number
US04996328

Reaction notes

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