Glycerol → Chlorohexidine

HRID 982574Notes

Reaction equation

HRID 982574 reaction equation
CC(O)=O.CC(O)=O.[CH:9]1[C:10]([NH:16]/[C:17](/[NH2:42])=[N:18]/[C:19](/[NH2:41])=[N:20]/[CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26]/[N:27]=[C:28](\[NH2:40])/[N:29]=[C:30](\[NH2:39])/[NH:31][C:32]2[CH:37]=[CH:36][C:35]([Cl:38])=[CH:34][CH:33]=2)=[CH:11][CH:12]=[C:13]([Cl:15])[CH:14]=1.C[C@H]1C[C@@H](O)[C@H](C(C)C)CC1.O.OCC(CO)O>C(O)C.C(O)C(O)C>[CH:11]1[C:10]([NH:16][C:17]([NH:18][C:19]([NH:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][NH:27][C:28]([NH:29][C:30]([NH:31][C:32]2[CH:37]=[CH:36][C:35]([Cl:38])=[CH:34][CH:33]=2)=[NH:39])=[NH:40])=[NH:41])=[NH:42])=[CH:9][CH:14]=[C:13]([Cl:15])[CH:12]=1

Participants

7

Reactant 4

HCID 753GlycerolHCID 962WaterHCID 16666(-)-MentholHCID 178476578HCID 178476578, compound

Product 1

HCID 178512157Chlorohexidine

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 1030Propylene GlycolSolvent

Procedure

A mouthwash (oral rinse) formulation of the present invention was prepared according to the following method. 7.5 g of Lecithin E-80, 625 mg of chlorhexidine diacetate, 525 mg of Tween-80, 250 mg of D,L-Menthol and 30 mg of alpha-tocopherol acid succinate were dissolved in mixture of 20 ml of absolute ethyl alcohol and 10 ml of propylene glycol. The resultant stock solution was mixed with vigorous stirring with 480 ml of distilled water and 10 g of pure glycerol was added as sweetener to obtain a suspension. The suspension was then filtered sequentially first through a 0.45 micron and then through a 0.22 micron PTFE membrane.

Workup

  1. washA mouthwash (oral rinse) formulation of the present invention
  2. customwas prepared
  3. additionThe resultant stock solution was mixed
  4. additionwas added as sweetener
  5. customto obtain a suspension
  6. filtrationThe suspension was then filtered sequentially first through a 0.45 micron

Sources & evidence

ORD record
ord-717244c1029846dabf533e1a83e5a94f
Source dataset
uspto-grants-2005_03
Patent number
US06861060B1

Reaction notes

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