反应详情

温度

200 °C

A mixture of 2-(4-fluoro-phenyl)-3-(4-methanesulfonyl-phenyl)-6-methoxy-pyrazolo[1,5-b]pyridazine (321 mg) and pyridine hydrochloride (1.4 g) was heated to and at 200° C. in a sealed vessel (Reactivial™) for 3 hours. The cooled reaction was poured into water (20 ml), and extracted with ethyl acetate (3×30 ml). The combined organic extracts dried (MgSO4), filtered and evaporated in vacuo to give a solid which was triturated with diethyl ether to give the title compound as a beige solid (119 mg).

1. customThe cooled reaction
2. extractionextracted with ethyl acetate (3×30 ml)
3. dry with materialThe combined organic extracts dried (MgSO4)
4. filtrationfiltered
5. customevaporated in vacuo
6. customto give a solid which
7. customwas triturated with diethyl ether