反应详情

To a stirring solution of ethyl 7-hydroxythieno[3,2-b]pyridine-6-carboxylate (Elliot, R. L, O'Hanlon, P. J., Rogers, N. H. Tetrahedron 43 (14) 3295-3302 (1987)) (2.50 g, 10.96 mmol) in trifluomethanesulfonic acid (50 mL) at 0° C. was added N-iodo succinimide (2.46 g, 10.96 mmol) portion wise. The mixture was stirred for 1 hour, allowing the solution to warm to ambient temperature. Ice (50 g) was added and the resulting aqueous extracted with CH2Cl2 (3×100 mL). The organic layers were combined, dried over MgSO4 and solvent removed to afford 2.92 g title compound as a white solid.

1. extractionthe resulting aqueous extracted with CH2Cl2 (3×100 mL)
2. dry with materialdried over MgSO4 and solvent
3. customremoved