反应详情

温度

190 °C

A stirring mixture of ethyl 7-hydroxy-2-iodothieno[3,2-b]pyridine-6-carboxylate (1.5 g, 4.29 mmol) in 4-chlorobenzylamine (15 mL) was heated at 190° C. for 1 hour. The resulting dark solution was cooled to ambient temperature and 100 mL toluene added. The resulting solid was collected by filtration and dried at 50° C. for 16 h to afford 0.875 g title compound as a yellow solid.

1. temperatureThe resulting dark solution was cooled to ambient temperature
2. filtrationThe resulting solid was collected by filtration
3. customdried at 50° C. for 16 h