4-Chlorobenzylamine → HCID 10286976, compound

Participants

Reaction Conditions

Reaction Steps

Ethyl 2-(hydroxymethyl)-4-methyl-7-oxo-4,7-dihydrothieno[3,2-b]pyridine-6-carboxylate (250 mg, 0.94 mmol) was suspended in 4-chlorobenzylamine (2.0 mL, 16.4 mmol). The mixture was stirred at 80° C. for 16 hours before it was quenched with a mixture of 1.0 M hydrochloric acid (25 mL) and ice (5 g). The mixture was stirred at room temperature for 1 hr. The solid ppt. was collected by vacuum filtration and washed thoroughly with 50 mL of water. Drying in vacuo left a white solid (0.26 g).

Provenance & Evidence