Carbon tetrabromide → HCID 22320750, compound

Participants

Reaction Steps

A solution of 3-(4-Phenoxy-phenyl)-prop-2-yn-1-ol of Example 51 (415 mg, 1.85 mmol), triphenylphosphine (514 mg, 1.96 mmol), carbon tetrabromide (650 mg, 1.96 mmol) in THF (3 ml) was stirred at room temperature for 3 days. Evaporation of the solution, and chromatography of the residue gave the title compound as a brown oil: NMR (CDCl3) δ 4.16 (s, 2H ), 6.91 (d, J=2.1, 1H ), 6.93 (d, J=2.1, 1H ), 7.01 (d, J=0.93, 1H), 7.04 (d, J=1.14, 1H ), 7.12-7.17 (m, 1H ), 7.36 (d, J=0.75, 1H ), 7.39(d, J=1.98, 2H ), 7.42 (d, J=2.64, 1H ). MS m/z 288 (M+1 calcd. for C15H11BrO 287.155)

Provenance & Evidence