Dimethylamine → 4-dimethylaminomethyl-2-isobutyl-6-phenyl-2H-pyridazin-3-one

HRID 982764Notes

Reaction equation

HRID 982764 reaction equation
[CH2:1]([N:5]1[C:10](=[O:11])[C:9]([CH2:12]OS(C)(=O)=O)=[CH:8][C:7]([C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)=[N:6]1)[CH:2]([CH3:4])[CH3:3].[CH3:24][NH:25][CH3:26]>>[CH3:24][N:25]([CH2:12][C:9]1[C:10](=[O:11])[N:5]([CH2:1][CH:2]([CH3:4])[CH3:3])[N:6]=[C:7]([C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)[CH:8]=1)[CH3:26]

Participants

3

Reactant 2

HCID 674DimethylamineHCID 219915622-isobutyl-4-methanesulfonyloxymethyl-6-phenyl-2H-pyridazin-3-one

Product 1

HCID 219915864-dimethylaminomethyl-2-isobutyl-6-phenyl-2H-pyridazin-3-oneYield 81.1%

Procedure

Following the procedure of Example 7, 2-isobutyl-4-methanesulfonyloxymethyl-6-phenyl-2H-pyridazin-3-one and dimethylamine were reacted to yield the title compound as a yellow oil (yield: 81.1%).

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-1d0193f56aaf4307a7c73bcb8ede9b54
Source dataset
uspto-grants-2005_03
Patent number
US06861428B2

Reaction notes

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