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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 982777Generated: October 31, 2026

1-Methylpiperazine → 6-(2,4-difluorophenyl)-2-isobutyl-4-(4-methyl-1-piperazinyl)methyl-2H-pyridazin-3-one

https://huagongshe.com/reaction/982777

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-MethylpiperazineHCID 53167—
Reactant6-(2,4-difluorophenyl)-2-isobutyl-4-methanesulfonyloxym ethyl-2H-pyridazin-3-oneHCID 21991416—
Product6-(2,4-difluorophenyl)-2-isobutyl-4-(4-methyl-1-piperazinyl)methyl-2H-pyridazin-3-oneHCID 2199154994%

Reaction Steps

Following the procedure of Example 1(10), 6-(2,4-difluorophenyl)-2-isobutyl-4-methanesulfonyloxymethyl-2H-pyridazin-3-one and 1-methylpiperazine were reacted to yield the title compound as a pale yellow oil (yield: 94.0%).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06861428B2
Source datasetuspto-grants-2005_03
ORD IDord-2cb5a1363c6f4a658d6a6aea156ad094
Source noteuspto-grants-2005_03