HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Chlorobenzyl chloride → 4-carboxy-2-(2-chlorobenzyl)-6-(4-fluoro-3-methylphenyl)-2H-pyridazin-3-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Chlorobenzyl chloride | HCID 11906 | — |
| Reactant | 6-(4-fluoro-3-methylphenyl)-4-methoxycarbonyl-2H-pyridazin-3-one | HCID 21991459 | — |
| Product | 4-carboxy-2-(2-chlorobenzyl)-6-(4-fluoro-3-methylphenyl)-2H-pyridazin-3-one | HCID 22562303 | 76.4% |
Reaction Steps
Following the procedure of Example 1(6), 6-(4-fluoro-3-methylphenyl)-4-methoxycarbonyl-2H-pyridazin-3-one and 2-chlorobenzyl chloride were reacted. Without purification, the reaction product was reacted further following the procedure of Example 1(7) to yield the title compound as pale yellow needles (yield: 76.4%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06861428B2 |
| Source dataset | uspto-grants-2005_03 |
| ORD ID | ord-92688586141d43a6b03b60f17ecda606 |
| Source note | uspto-grants-2005_03 |