3-(2-Chlorophenyl)-1-propanol methanesulfonate → HCID 22562287, compound

HRID 982832Notes

Reaction equation

HRID 982832 reaction equation
[F:1][C:2]1([O:19][CH3:20])[CH:7]=[CH:6][CH:5]=[C:4]([C:8]2[CH:9]=[C:10]([C:15]([O:17]C)=[O:16])[C:11](=[O:14])[NH:12][N:13]=2)[CH2:3]1.CS(O[CH2:26][CH2:27][CH2:28][C:29]1[CH:34]=[CH:33][CH:32]=[CH:31][C:30]=1[Cl:35])(=O)=O>>[C:15]([C:10]1[C:11](=[O:14])[N:12]([CH2:26][CH2:27][CH2:28][C:29]2[CH:34]=[CH:33][CH:32]=[CH:31][C:30]=2[Cl:35])[N:13]=[C:8]([C:4]2[CH2:3][C:2]([F:1])([O:19][CH3:20])[CH:7]=[CH:6][CH:5]=2)[CH:9]=1)([OH:17])=[O:16]

Participants

3

Reactant 2

HCID 196884483-(2-Chlorophenyl)-1-propanol methanesulfonateHCID 22562304HCID 22562304, compound

Product 1

HCID 22562287HCID 22562287, compoundYield 56%

Procedure

Following the procedure of Example 1(6), 6-(3-fluoro-3-methoxyphenyl)-4-methoxycarbonyl-2H-pyridazin-3-one and 3-(2-chlorophenyl)-1-propanol methanesulfonate were reacted. Without purification, the reaction product was reacted further following the procedure of Example 1(7) to yield the title compound as a pale yellow solid (yield: 56.0%).

Workup

  1. customwere reacted
  2. customWithout purification
  3. customthe reaction product was reacted further

Sources & evidence

ORD record
ord-d82e155ad3cd45249213ba5a82969e31
Source dataset
uspto-grants-2005_03
Patent number
US06861428B2

Reaction notes

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