Lithium Hydroxide → HCID 22184909, compound

Participants

Reaction Steps

To a solution of 2-((ethoxycarbonyl)methylcarbonylamino)naphthalene (2.3 g, 8.9 mmol) in MeOH (40 mL) was added a solution of LiOH (1.18 g, 27 mmol) in water (40 mL). The reaction mixture was stirred at ambient temperature. After 3 hours, the reaction mixture was acidified to pH 2-3 by 2N NaHSO4, then extracted with ethyl acetate (3×50 mL). The organic layer was dried over Na2SO4 and evaporated in vacuo to afford 2-((carboxy)methylcarbonyl-amino)naphthalene (2.0 g, 8.7 mmol) as a solid that was used in further preparations without further purification.

Provenance & Evidence