HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → (2R,4R)-4-hydroxy-pyrrolidine-2-carboxylic acid cyclopropylamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | (2R,4R)-2-cyclopropylcarbamoyl-4-hydroxy-pyrrolidine-1-carboxylic acid tert-butyl ester | HCID 69741572 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | (2R,4R)-4-hydroxy-pyrrolidine-2-carboxylic acid cyclopropylamide | HCID 28943484 | 95.3% |
Reaction Steps
(2R,4R)-2-Cyclopropylcarbamoyl-4-hydroxy-pyrrolidine-1-carboxylic acid tert-butyl ester (5 g) was deprotected using 50 mL of 30% TFA in DCM at rt for 2 hours to give 3 g of (2R,4R)-4-hydroxy-pyrrolidine-2-carboxylic acid cyclopropylamide as a light yellow oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06861418B2 |
| Source dataset | uspto-grants-2005_03 |
| ORD ID | ord-4716e4eee94b41a582fafb121492f75e |
| Source note | uspto-grants-2005_03 |