HuagongsheHuagongshe Chemistry Print Report · For research reference only
Aluminium lithium hydride → HCID 69741629, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Aluminium lithium hydride | HCID 21226445 | — |
| Reactant | (2R,4R)-4-hydroxy-pyrrolidine-2-carboxylic acid cyclopropylamide | HCID 28943484 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 69741629 | HCID 69741629 | 36.3% |
Reaction Steps
1H NMR (400 MHz, DMSO-d6)δ 4.32 (m, 1H), 4.1 (m, 1H), 3.2 (m 2H), 2.67 (m, 1H), 2.35 (m, 1H), 1.85 (m, 1H), 0.67 (m, 2H), 0.45 (m, 2H). [486] (2R,4R)-4-Hydroxy-pyrrolidine-2-carboxylic acid cyclopropylamide (3 g) was reduced using LAH (2 g) in THF (150 mL) to give 1 g of (3R,5R)-5-cyclopropylaminomethyl-pyrrolidin-3-ol.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06861418B2 |
| Source dataset | uspto-grants-2005_03 |
| ORD ID | ord-98c9ee36a0df4f7095ff133d1ff82d53 |
| Source note | uspto-grants-2005_03 |