HuagongsheHuagongshe Chemistry Print Report · For research reference only
Phenylacetyl chloride → N-(phenylacetyl)-L-alanine isobutyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Phenylacetyl chloride | HCID 7679 | — |
| Reactant | 2-Methylpropyl (2S)-2-aminopropanoate hydrochloride | HCID 86584981 | — |
| Product | N-(phenylacetyl)-L-alanine isobutyl ester | HCID 15480460 | — |
Reaction Steps
Following General Procedure B′ and using phenylacetyl chloride (Aldrich) and L-alanine iso-butyl ester hydrochloride (from Example B′ above), the title compound was prepared as a solid having a melting point of 45°-47° C. The reaction was monitored by tlc on silica gel and purification was by extraction with Et2O followed by washes with aqueous K2CO3 and aqueous HCl.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06861558B2 |
| Source dataset | uspto-grants-2005_03 |
| ORD ID | ord-b859f8f2ea5f42daadd99d0e1077d983 |
| Source note | uspto-grants-2005_03 |