2-(3-Methyl-1,2-oxazol-5-yl)acetic acid → N-[(3-methylisoxazol-5yl)acetyl]alanine Iso-butyl Ester

HRID 983224Notes

Reaction equation

HRID 983224 reaction equation
[CH3:1][C:2]1[CH:6]=[C:5]([CH2:7][C:8]([OH:10])=O)[O:4][N:3]=1.[CH2:11]([O:15][C:16](=[O:20])[C@H:17]([CH3:19])[NH2:18])[CH:12]([CH3:14])[CH3:13]>>[CH2:11]([O:15][C:16](=[O:20])[C@H:17]([CH3:19])[NH:18][C:8](=[O:10])[CH2:7][C:5]1[O:4][N:3]=[C:2]([CH3:1])[CH:6]=1)[CH:12]([CH3:14])[CH3:13]

Participants

3

Reactant 2

HCID 41955322-(3-Methyl-1,2-oxazol-5-yl)acetic acidHCID 137435562-methylpropyl (2S)-2-aminopropanoate

Product 1

HCID 15481782N-[(3-methylisoxazol-5yl)acetyl]alanine Iso-butyl Ester

Procedure

Following General Procedure I′ above, and using (3-methyl-isoxazol-5-yl)acetic acid (CAS# 19668-85-0) and alanine iso-butyl ester (prepared following General Procedure J′ above), the title compound was prepared. The reaction was monitored by tlc on silica gel and purification was by filtration as described in the general procedure.

Workup

  1. customprepared

Sources & evidence

ORD record
ord-237a38532cff4551ad18fe412a63d77b
Source dataset
uspto-grants-2005_03
Patent number
US06861558B2

Reaction notes

Loading…