2-methylpropyl (2S)-2-aminopropanoate → N-[(2-phenylthiothienyl)acetyl]alanine iso-butyl ester

HRID 983225Notes

Reaction equation

HRID 983225 reaction equation
[C:1]1([S:7][C:8]2[S:9][CH:10]=[CH:11][C:12]=2[CH2:13][C:14]([OH:16])=O)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH2:17]([O:21][C:22](=[O:26])[C@H:23]([CH3:25])[NH2:24])[CH:18]([CH3:20])[CH3:19]>>[CH2:17]([O:21][C:22](=[O:26])[C@H:23]([CH3:25])[NH:24][C:14](=[O:16])[CH2:13][C:12]1[CH:11]=[CH:10][S:9][C:8]=1[S:7][C:1]1[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1)[CH:18]([CH3:20])[CH3:19]

Participants

3

Reactant 2

HCID 137435562-methylpropyl (2S)-2-aminopropanoateHCID 54517004(2-Phenylthiothienyl)acetic acid

Product 1

HCID 53734580N-[(2-phenylthiothienyl)acetyl]alanine iso-butyl ester

Procedure

Following General Procedure I′ above, and using (2-phenylthiothienyl)acetic acid and alanine iso-butyl ester (prepared following General Procedure J′ above), the title compound was prepared. The reaction was monitored by tlc on silica gel and purification was by filtration as described in the general procedure.

Workup

  1. customprepared

Sources & evidence

ORD record
ord-544188c521cc45cf8a5743c0d9c9618f
Source dataset
uspto-grants-2005_03
Patent number
US06861558B2

Reaction notes

Loading…