3-Nitrophenylacetic acid → N-[(3-nitrophenyl)acetyl]methionine Ethyl Ester

HRID 983234Notes

Reaction equation

HRID 983234 reaction equation
[N+:1]([C:4]1[CH:5]=[C:6]([CH2:10][C:11]([OH:13])=O)[CH:7]=[CH:8][CH:9]=1)([O-:3])=[O:2].Cl.[CH2:15]([O:17][C:18](=[O:25])[C@H:19]([CH2:21][CH2:22][S:23][CH3:24])[NH2:20])[CH3:16]>>[CH2:15]([O:17][C:18](=[O:25])[C@H:19]([CH2:21][CH2:22][S:23][CH3:24])[NH:20][C:11](=[O:13])[CH2:10][C:6]1[CH:7]=[CH:8][CH:9]=[C:4]([N+:1]([O-:3])=[O:2])[CH:5]=1)[CH3:16]

Participants

3

Reactant 2

HCID 158763-Nitrophenylacetic acidHCID 3083785Ethyl L-methionate hydrochloride

Product 1

HCID 53910855N-[(3-nitrophenyl)acetyl]methionine Ethyl Ester

Procedure

Following General Procedure G′ above and using 3-nitrophenylacetic acid (Aldrich) and methionine ethyl ester hydrochloride (Aldrich), the title compound was prepared. The reaction was monitored by tlc on silica gel and purification was by recrystallization from butyl chloride.

Workup

  1. customThe reaction was monitored by tlc on silica gel and purification
  2. customwas by recrystallization from butyl chloride

Sources & evidence

ORD record
ord-b8c5659cf16844cab33cfa7ece12b175
Source dataset
uspto-grants-2005_03
Patent number
US06861558B2

Reaction notes

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