HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(Chloromethyl)pyridinium chloride → HCID 10201279, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(Chloromethyl)pyridinium chloride | HCID 74570 | — |
| Reactant | (2S)-2-[[2-(3,5-difluorophenyl)acetyl]amino]propanoic acid | HCID 12135350 | — |
| Reactant | HCID 67278504 | HCID 67278504 | — |
| Product | HCID 10201279 | HCID 10201279 | — |
Reaction Steps
Following General Procedure A and using N-(3,5-difluorophenylacetyl)-L-alanine (from Example B2 above) and methyl (S)-2-amino-3-(4-pyridyl)propionate hydrochloride (prepared by the method set forth above using 4-picolylchloride hydrochloride), the title compound was prepared as a solid. The reaction was monitored by tlc (Rf=0.49 in 10% MeOH/DCM) and the product was purified by silica gel column chromatography.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06861558B2 |
| Source dataset | uspto-grants-2005_03 |
| ORD ID | ord-b2dcd54266064f13af2aaa46179c01f2 |
| Source note | uspto-grants-2005_03 |