HuagongsheHuagongshe Chemistry Print Report · For research reference only
Glycine methyl ester hydrochloride → HCID 9944662, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Glycine methyl ester hydrochloride | HCID 122755 | — |
| Reactant | (2S)-2-[[2-(3,5-difluorophenyl)acetyl]amino]propanoic acid | HCID 12135350 | — |
| Solvent | Dichloromethane methanol | HCID 21226129 | — |
| Product | HCID 9944662 | HCID 9944662 | — |
Reaction Steps
Following General Procedure A and using N-(3,5-difluorophenylacetyl)-L-alanine (from Example B2 above) and glycine methyl ester hydrochloride (Bachem), the tide compound was prepared as a solid (mp=158-160° C.). The reaction was monitored by tlc (Rf=0.61 in 10% MeOH/DCM) and the product was purified by silica gel chromatography.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06861558B2 |
| Source dataset | uspto-grants-2005_03 |
| ORD ID | ord-46c01fe866034107b843f44cde3bcd92 |
| Source note | uspto-grants-2005_03 |