HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl L-phenylalaninate hydrochloride → N-[N-(Cyclohex-1-enylacety)-L-alaninyl]-L-phenylalanine Methyl Ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl L-phenylalaninate hydrochloride | HCID 75736 | — |
| Reactant | Tert-butoxycarbonylalanine | HCID 85082 | — |
| Reactant | 1-Cyclohexene-1-acetic acid | HCID 86699 | — |
| Reactant | Alanylphenylalanine methyl ester | HCID 12988705 | — |
| Product | N-[N-(Cyclohex-1-enylacety)-L-alaninyl]-L-phenylalanine Methyl Ester | HCID 10177298 | — |
Reaction Steps
Following General Procedure U and using cyclohex-1-enylacetic acid (Alfa) and N-(L-alaninyl)-L-phenylalanine methyl ester (prepared by coupling N-BOC-L-alanine (Bachem) with L-phenylalanine methyl ester hydrochloride (Bachem) using General Procedure U, followed by removal of the BOC-group using General Procedure Y), the title compound was prepared as a solid (mp=139-142° C.). The reaction was monitored by tlc (Rf=0.27 in 1:1 EtOAc/hexanes).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06861558B2 |
| Source dataset | uspto-grants-2005_03 |
| ORD ID | ord-999dd48edb8548149440c74562b8825a |
| Source note | uspto-grants-2005_03 |