HuagongsheHuagongshe Chemistry Print Report · For research reference only
Morpholine → 4[N-[N-(3-Nitrophenylacetyl)-L-alaninyl]-(S)-2-amino-3-tert-butoxybutyryl]morpholine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Morpholine | HCID 8083 | — |
| Reactant | (2S,3R)-3-(tert-butoxy)-2-(((tert-butoxy)carbonyl)amino)butanoic acid | HCID 7015770 | — |
| Reactant | N-(3-Nitrophenylacetyl)-L-alanine | HCID 53788870 | — |
| Reactant | 4-((S)-2-amino-3-tert-butoxybutyryl]-morpholine | HCID 69623029 | — |
| Solvent | Chloroform methanol | HCID 21584188 | — |
| Product | 4[N-[N-(3-Nitrophenylacetyl)-L-alaninyl]-(S)-2-amino-3-tert-butoxybutyryl]morpholine | HCID 69622795 | — |
Reaction Steps
Following General Procedure C and using N-(3-nitrophenylacetyl)-L-alanine (from Example D11 above) and 4-[(S)-2-amino-3-tert-butoxybutyryl]-morpholine (prepared from N-BOC-O-tert-butyl-L-threonine (Sigma) and morpholine (Aldrich) using General Procedure M, followed by removal of the BOC-group using General Procedure P), the title compound was prepared as a solid. The reaction was monitored by tlc (Rf=0.1 in 95:5 CHCl3/MeOH) and the product was purified by silica gel chromatography using 96:4 CHCl3/MeOH as the eluent.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06861558B2 |
| Source dataset | uspto-grants-2005_03 |
| ORD ID | ord-ddd489fe1ad04a6993c62f7a28f20e2c |
| Source note | uspto-grants-2005_03 |