HuagongsheHuagongshe Chemistry Print Report · For research reference only
Leucine methyl ester hydrochloride → N-[N-(3,5-Difluorophenylacetyl)-L-alaninyl]-L-leucine Methyl Ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Leucine methyl ester hydrochloride | HCID 2723695 | — |
| Reactant | (2S)-2-[[2-(3,5-difluorophenyl)acetyl]amino]propanoic acid | HCID 12135350 | — |
| Solvent | Chloroform methanol | HCID 21584188 | — |
| Product | N-[N-(3,5-Difluorophenylacetyl)-L-alaninyl]-L-leucine Methyl Ester | HCID 22894890 | — |
Reaction Steps
Following General Procedure C and using N-(3,5-difluorophenylacetyl)-L-alanine (from Example B2 above) and L-leucine methyl ester hydrochloride (Aldrich), the title compound was prepared as a solid. The reaction was monitored by tlc (Rf=0.5 in 9:1 CHCl3/MeOH).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06861558B2 |
| Source dataset | uspto-grants-2005_03 |
| ORD ID | ord-920b2b1b77a649e8a1fd8d6bd701185b |
| Source note | uspto-grants-2005_03 |