HuagongsheHuagongshe Chemistry Print Report · For research reference only
(2S)-2-[[2-(3,5-difluorophenyl)acetyl]amino]propanoic acid → HCID 20640034, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (2S)-2-[[2-(3,5-difluorophenyl)acetyl]amino]propanoic acid | HCID 12135350 | — |
| Reactant | Methyl 4-amino-2,4,5-trideoxy-5-phenyl-L-threo-pentonate | HCID 14453007 | — |
| Solvent | Chloroform methanol | HCID 21584188 | — |
| Product | HCID 20640034 | HCID 20640034 | — |
Reaction Steps
Following General Procedure C and using N-(3,5-difluorophenylacetyl)-L-alanine (from Example B2 above) and methyl (3S,4S)-4-amino-3-hydroxy-5-phenylpentanoate (Novabiochem), the title compound was prepared as a solid. The reaction was monitored by tlc (Rf=0.2 in 95:5 CHCl3/MeOH) and the product was purified by flash column chromatography using 95:5 CHCl3/MeOH as the eluent.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06861558B2 |
| Source dataset | uspto-grants-2005_03 |
| ORD ID | ord-930373f39bf744e7a3cceaa62b752b34 |
| Source note | uspto-grants-2005_03 |