反应详情

The title compound (0.04 g) was prepared from 2-amino-6-chloro-4-cyclopropyl-7-fluoro-5-methoxypyrido[1,2-c]pyrimidine-1,3-dione (0.09 g, 0.30 mmol [Example 12]), and methyl-((S)—(R)-1-pyrrolidin-3-ylethyl)amine (0.11 g, 0.90 mmol) using the general procedure of Example 4. 1H NMR (400 MHz, CDCl3) δ 8.20 (d, 1H), 5.42 (s, 2H), 3.89-3.58 (m, 5H), 3.22 (s, 3H), 2.67-2.58 (m, 1H), 2.46 (s, 3H), 2.22-2.02 (m, 2H), 1.80-1.61 (m, 2H), 1.21 (d, 3H), 1.10-1.00 (m, 1H), 0.84-0.76 (m, 1H), 0.52-0.44 (m, 1H), 0.40-0.32 (m, 1H). MSCI: m/z=392 (MH+).