HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 983415Generated: October 31, 2026
Lithium iodide → 4-(6-Cyano-5-hydroxy-pyridin-2-yl)-benzoic acid ethyl ester
https://huagongshe.com/reaction/983415
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Lithium iodide | HCID 66321 | — |
| Reactant | 4-(6-Cyano-5-methoxy-pyridin-2-yl)-benzoic acid ethyl ester | HCID 69356872 | — |
| Solvent | 2,4,6-Trimethylpyridine | HCID 7953 | — |
| Product | 4-(6-Cyano-5-hydroxy-pyridin-2-yl)-benzoic acid ethyl ester | HCID 69359527 | — |
Reaction Steps
A solution of 4-(6-cyano-5-methoxy-pyridin-2-yl)-benzoic acid ethyl ester from Example 13d in collidine is treated with LiI and heated at 120° C. for 24 h. The reaction mixture is evaporated, the residue is taken into water and neutralized with 1 N HCl. The resulting precipitate is collected and dried to give 4-(6-cyano-5-hydroxy-pyridin-2-yl)-benzoic acid ethyl ester.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US06864267B2 |
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| Source dataset | uspto-grants-2005_03 |
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| ORD ID | ord-da5589dd4c5e468882903486c4d0c31f |
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| Source note | uspto-grants-2005_03 |
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