Methyl Isocyanate → HCID 21362789, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of (7-methoxy-1,2,3,4-tetrahydro-naphthalen-2-yl)-piperidin-4-ylmethyl-propyl-amine (200 μL of a 0.25 M solution in dichloromethane, 50 μmole) was added 220 μL of a 0.25 M solution of methyl isocyanate in acetonitrile and 30 μL of DIEA. The solution was allowed to stir for 24 h at 25° C. under N2 and then concentrated in vacuo. The final product was isolated by preparative RPHPLC (YMC Combiprep ODS-A column, 10-90% acetonitrile: water (0.1 % TFA)) to afford 4-{[(7-methoxy-1,2,3,4-tetrahydro-naphthalen-2-yl)-propyl-amino]-methyl}-piperidine-1-carboxylic acid methylamide (17.1 mg) 25 [M+H]+=374.

Provenance & Evidence