反应详情

A solution of 4-hydroxy-chromen-2-one (650 mg) and 2-carboxybenzyladehyde (300 mg) in EtOH was heated to reflux for 4 hours, cooled to room temperature then concentrated in vacuo to give a crude oil, which was diluted with water. The precipitated 4-hydroxy-chromen-2-one was collected by filtration (490 mg). A second crop of solid was collected from the mother liquor and triturated with hot EtOAc and filtered to provide 4-Hydroxy-3-(3-oxo-1,3-dihydro-isobenzofuran-1-yl)-chromen-2-one as white solid. MS: 293 [M-H].

1. temperatureto reflux for 4 hours
2. concentrationthen concentrated in vacuo
3. customto give a crude oil, which
4. filtrationThe precipitated 4-hydroxy-chromen-2-one was collected by filtration (490 mg)
5. customA second crop of solid was collected from the mother liquor
6. customtriturated with hot EtOAc
7. filtrationfiltered