HCID 131724776, compound → HCID 87999682, compound

Participants

Reaction Steps

To a solution of imidate 37 prepared above in CH2Cl2 (5 mL) was added 42 (16 mg, 0.033 mmol) in CH2Cl2 (1 mL), followed by ZnCl2 (0.6 mL of a 1M solution in ether, 0.6 mmol). The mixture was stirred at room temperature for 2 hours. After aqueous work-up (CH2Cl2) and purification by PTLC, about 12.6 mg of crude product 43 (•- and •-isomers) was obtained. To a solution of this crude product 43 (4 mg) in CH3OH (2 mL) was added K2CO2 (20 mg). The mixture was stirred at room temperature for about two hours. After aqueous work-up (CH2Cl2) and purification by HPLC, about 1 mg of 44 was obtained.

Provenance & Evidence