Hydrochloric Acid → 4-(Ethyl(2-hydroxyethyl)amino)benzaldehyde

Participants

Reaction Conditions

Reaction Steps

A 150 ml of NaOH-solution (5 M in water) is added to a solution of 59.2 g (252 mmol) of 17 in 200 ml of ethanol and the mixture is stirred overnight at 40° C. The reaction mixture is cooled in an ice bath and neutralized with HCl (5 M) and extracted with dichloromethane. The organic layer is washed with a saturated NaHCO3-solution, with brine and dried over MgSO4. The solvents are evaporated under reduced pressure. The product is isolated as an oil and used without further purification.

Provenance & Evidence