HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium hydride → 4-trifluoromethyl-1-(2-trimethylsilanyl-ethoxymethyl)-1H-imidazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | 2-Chloromethyl 2-(trimethylsilyl)ethyl ether | HCID 2724271 | — |
| Reactant | HCID 178418921 | HCID 178418921 | — |
| Product | 4-trifluoromethyl-1-(2-trimethylsilanyl-ethoxymethyl)-1H-imidazole | HCID 13600232 | — |
Reaction Steps
Reaction of 4-trifluoromethyl-1H-imidazole (301 mg, 2.21 mmol), 95% NaH (61 mg, 2.4 mmol), and SEMCl (406 mg, 2.44 mmol) gave the title compound as a brown oil that was used without further purification. 1H NMR (CDCl3) □0.00 (s, 9H), 0.93 (m, 2H), 3.51 (m, 2H), 5.30 (s, 2H), 7.39 (s, 1H), 7.64 (s, 1H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06864265B2 |
| Source dataset | uspto-grants-2005_03 |
| ORD ID | ord-e9e38798db334173a3ed431ebfe9b37b |
| Source note | uspto-grants-2005_03 |