反应详情

4-phenyl-2-methylenebutyric acid, ethyl ester (10 g, 49 mmole) was dissolved in 100 mL of absolute ethanol, Potassium hydroxide (3.32 g, 85%, 50 mmole) was added to the solution and the solution stirred overnight at room temperature. After 18 hours, all of the ester was hydolyzed. The solvent was removed under reduced pressure and the syrup dissolved in water. Enough concentrated HCl was added to acidify the solution (pH>3) and the product was extracted with ether (3×50 mL). The solution was dried over MgSO4, filtered and the solvent removed under reduced pressure. Recovered 8.6 g of product (97% yield).

1. waitAfter 18 hours
2. customThe solvent was removed under reduced pressure
3. dissolutionthe syrup dissolved in water
4. additionEnough concentrated HCl was added
5. extractionthe product was extracted with ether (3×50 mL)
6. dry with materialThe solution was dried over MgSO4
7. filtrationfiltered
8. customthe solvent removed under reduced pressure