反应详情

A mixture of 143.4 grams of aluminum chloride and 351.6 grams of benzene was stirred at room temperature while 100 grams of 3,5,5-trimethylhexanoyl chloride was added to the reaction keeping the reaction temperature at approximately 35° C. over a period of 1.5 hours. The mixture was then stirred for 3 hours. The reaction mixture was poured into 500 grams of ice and stirred until all the ice dissolved. Water was added with cooling to give a homogenous mixture followed by extraction with 400 mL of ethyl acetate. The organic phase was washed with brine, dried with anhydrous magnesium sulfate and stripped to dryness to give 3,5,5-Trimethylhexanoylbenzene.

1. additionwas added to the reaction
2. customat approximately 35° C.
3. customof 1.5 hours
4. dissolutiondissolved
5. temperaturewith cooling
6. customto give a homogenous mixture
7. extractionfollowed by extraction with 400 mL of ethyl acetate
8. washThe organic phase was washed with brine
9. dry with materialdried with anhydrous magnesium sulfate