Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2-Bromo-2-methylpropionyl bromide → 8-bromo-4-(2-fluorobenzenesulfonyl)-2,2-dimethyl-3,4-dihydro-2H-benzo[1,4]oxazine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2-Bromo-2-methylpropionyl bromide | HCID 88685 | — |
| 반응물 | 2-Fluorobenzenesulphonyl chloride | HCID 137761 | — |
| 반응물 | 2-Amino-6-bromophenol | HCID 15531506 | — |
| 반응물 | 8-bromo-2,2-dimethyl-3,4-dihydro-2H-1,4-benzoxazine | HCID 18449100 | — |
| 반응물 | 8-Bromo-2,2-dimethyl-2H-1,4-benzoxazin-3(4H)-one | HCID 21873511 | — |
| 생성물 | 8-bromo-4-(2-fluorobenzenesulfonyl)-2,2-dimethyl-3,4-dihydro-2H-benzo[1,4]oxazine | HCID 22557282 | — |
반응 단계
Using the above procedure, but starting with 8-bromo-2,2-dimethyl-3,4-dihydro-2H-benzo[1,4]oxazine (prepared by reducing 8-bromo-2,2-dimethyl-4H-benzo[1,4]oxazin-3-one, which in turn was prepared from 2-amino-6-bromophenol and 2-bromo-2-methylproprionyl bromide via the procedure described by Van Hes et al., WO 01/14330) and 2-fluorobenzenesulfonyl chloride, 8-bromo-4-(2-fluorobenzenesulfonyl)-2,2-dimethyl-3,4-dihydro-2H-benzo[1,4]oxazine was obtained as a white solid. MP.: 108.0-110.1°.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06867204B2 |
| 출처 데이터셋 | uspto-grants-2005_03 |
| ORD ID | ord-18b0a5ba2ab245f88e499356587a0686 |
| 출처 메모 | uspto-grants-2005_03 |