2,4-Dichlorobenzylidenemalononitrile → 5-Aminomethyl-6-(2,4-dichloro-phenyl)-2-thiophen-2-yl-pyrimidin-4-ylamine

HRID 983848Notes

Reaction equation

HRID 983848 reaction equation
[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[C:6]([NH2:8])=[NH:7].[Cl:9][C:10]1[CH:21]=[C:20]([Cl:22])[CH:19]=[CH:18][C:11]=1[CH:12]=[C:13]([C:16]#[N:17])[C:14]#[N:15]>>[NH2:17][CH2:16][C:13]1[C:14]([NH2:15])=[N:7][C:6]([C:2]2[S:1][CH:5]=[CH:4][CH:3]=2)=[N:8][C:12]=1[C:11]1[CH:18]=[CH:19][C:20]([Cl:22])=[CH:21][C:10]=1[Cl:9]

Participants

3

Reactant 2

HCID 180892,4-DichlorobenzylidenemalononitrileHCID 2781760Thiophene-2-carboximidamide

Product 1

HCID 222206085-Aminomethyl-6-(2,4-dichloro-phenyl)-2-thiophen-2-yl-pyrimidin-4-ylamine

Procedure

The title compound, MS: m/e=351.2 (M+H+), was prepared from thiophene-2-carboxamidine and 2-(2,4-dichloro-benzylidene)-malononitrile in analogy to the process described in Example 11 as a solid.

Sources & evidence

ORD record
ord-b2f5fb449ab349bfac8d5f99cbc54a44
Source dataset
uspto-grants-2005_03
Patent number
US06867205B2

Reaction notes

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