2,4-Dichlorobenzylidenemalononitrile → 5-(Aminomethyl)-6-(2,4-dichlorophenyl)-2-(2-fluorophenyl)pyrimidin-4-amine

HRID 983849Notes

Reaction equation

[F:1][C:2]1[CH:10]=[CH:9][CH:8]=[CH:7][C:3]=1[C:4]([NH2:6])=[NH:5].[Cl:11][C:12]1[CH:23]=[C:22]([Cl:24])[CH:21]=[CH:20][C:13]=1[CH:14]=[C:15]([C:18]#[N:19])[C:16]#[N:17]>>[NH2:19][CH2:18][C:15]1[C:16]([NH2:17])=[N:5][C:4]([C:3]2[CH:7]=[CH:8][CH:9]=[CH:10][C:2]=2[F:1])=[N:6][C:14]=1[C:13]1[CH:20]=[CH:21][C:22]([Cl:24])=[CH:23][C:12]=1[Cl:11]

Participants

Reactant 2

HCID 180892,4-Dichlorobenzylidenemalononitrile

HCID 43230592-Fluorobenzamidine

Product 1

HCID 102156285-(Aminomethyl)-6-(2,4-dichlorophenyl)-2-(2-fluorophenyl)pyrimidin-4-amine

Procedure

The title compound, MS: m/e=363.0 (M+H+), was prepared from 2-fluorobenzamidine and 2-(2,4-dichloro-benzylidene)-malononitrile in analogy to the process described in Example 11 as a solid.

Sources & evidence

ORD record: ord-1cf31fce8c0f4a4c993410601e7965c7
Source dataset: uspto-grants-2005_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06867205B2

Reaction notes

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