2,4-Dichlorobenzylidenemalononitrile → 5-(Aminomethyl)-6-(2,4-dichlorophenyl)-2-(2-methoxyphenyl)pyrimidin-4-amine

HRID 983864Notes

Reaction equation

HRID 983864 reaction equation
[CH3:1][O:2][C:3]1[CH:11]=[CH:10][CH:9]=[CH:8][C:4]=1[C:5]([NH2:7])=[NH:6].[Cl:12][C:13]1[CH:24]=[C:23]([Cl:25])[CH:22]=[CH:21][C:14]=1[CH:15]=[C:16]([C:19]#[N:20])[C:17]#[N:18]>>[NH2:20][CH2:19][C:16]1[C:17]([NH2:18])=[N:6][C:5]([C:4]2[CH:8]=[CH:9][CH:10]=[CH:11][C:3]=2[O:2][CH3:1])=[N:7][C:15]=1[C:14]1[CH:21]=[CH:22][C:23]([Cl:25])=[CH:24][C:13]=1[Cl:12]

Participants

3

Reactant 2

HCID 180892,4-DichlorobenzylidenemalononitrileHCID 43218342-Methoxy-benzamidine

Product 1

HCID 103092955-(Aminomethyl)-6-(2,4-dichlorophenyl)-2-(2-methoxyphenyl)pyrimidin-4-amine

Procedure

The title compound, MS: m/e=374.8 (M+H+), was prepared from 2-methoxybenzamidine and 2-(2,4-dichloro-benzylidene)-malononitrile in analogy to the process described in Example 11 as a solid.

Sources & evidence

ORD record
ord-74f02427ba3b4d30add11b213179a432
Source dataset
uspto-grants-2005_03
Patent number
US06867205B2

Reaction notes

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