HuagongsheHuagongshe Chemistry Print Report · For research reference only
Phosphorus oxychloride → 4-Chloroquinoline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Phosphorus oxychloride | HCID 24813 | — |
| Reactant | quinolin-4-ol | HCID 178516385 | — |
| Product | 4-Chloroquinoline | HCID 69140 | — |
Reaction Steps
In this scheme, the ethyl ester (A1) is condensed with the appropriate aniline (A2), in the presence of acid, to form an imine. The imine is then cyclized by heating at about 260-280° C. to give the corresponding 4-hydroxyquinoline (A3). The 4-hydroxyquinoline (A3) is subsequently refluxed with phosphorous oxychloride to form a 4-chloroquinoline (A4).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06867185B2 |
| Source dataset | uspto-grants-2005_03 |
| ORD ID | ord-992e4ca67ad14daa942f7b8c9204d3bc |
| Source note | uspto-grants-2005_03 |