Iodine → 6-(1-fluoroethyl)-5-iodo-4-pyrimidone

HRID 983904Notes

Reaction equation

HRID 983904 reaction equation
[F:1][CH:2]([C:4]1[N:9]=[CH:8][NH:7][C:6](=[O:10])[CH:5]=1)[CH3:3].[I:11]Cl.II.ClCl>C(O)(=O)C>[F:1][CH:2]([C:4]1[N:9]=[CH:8][NH:7][C:6](=[O:10])[C:5]=1[I:11])[CH3:3]

Participants

6

Reactant 4

HCID 807IodineHCID 24526ChlorineHCID 24640Iodine chlorideHCID 1354718076-(1fluoroethyl)-4-pyrimidone

Product 1

HCID 1354334396-(1-fluoroethyl)-5-iodo-4-pyrimidone

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent3×

Procedure

To an acetic acid (150 ml) solution of 6-(1fluoroethyl)-4-pyrimidone (56.8 g) was added dropwise under room temperature and stirring an acetic acid solution of iodine monochloride prepared by adding iodine (50.8 g) to acetic acid (500 ml) and blowing chlorine (15 g) thereinto under room temperature and stirring, and the resulting mixture was stirred for 6 hours.

Workup

  1. customprepared
  2. stirringthe resulting mixture was stirred for 6 hours

Sources & evidence

ORD record
ord-4abd0c6191b643289218bc490ab01772
Source dataset
uspto-grants-2005_03
Patent number
US06867212B2

Reaction notes

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