Carbon Dioxide → HCID 9813967, compound

Participants

Reaction Steps

3-(2-Thienyl)-2-(4-pyridyl)-6,7-dihydro-5H-pyrrolizine-1-carboxylic acid (example 7, 0.2 g, 0.64 mmol) is heated under argon in a 10 ml flask by immersing in a metal bath at 250° C. Evolution of CO2 takes place immediately, and the substance melts and turns black. After cooling, the solidified, glassy melt is taken up in CH2Cl2 (10 ml) and filtered through Al2O3 (TSC, Baker). The filter cake is eluted with diethyl ether. The eluate is concentrated and crystallizes from ether/diisopropyl ether in the cold: white crystals 0.04 g.

Provenance & Evidence