HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → Ethyl 3-(4-fluorobenzoyl)-2-thiazolidinecarboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 4-Fluorobenzoyl chloride | HCID 67879 | — |
| Reactant | HCID 208627 | HCID 208627 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | Ethyl 3-(4-fluorobenzoyl)-2-thiazolidinecarboxylate | HCID 22557518 | — |
Reaction Steps
The solution of ethyl thiazolidine-2-carboxylate (24.18 g, 0.15 mol) in abs. CH2Cl2 (80 ml) is treated dropwise at RT with the solution of 4-fluorobenzoyl chloride (23.78, 0.15 mol) in abs. CH2Cl2 (20 ml). The solution warms to 38° C., the solvent begins to boil and HCl is released. It is kept under reflux for 4 h with heating.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06867211B2 |
| Source dataset | uspto-grants-2005_03 |
| ORD ID | ord-3258aa0bb5a0478ba7e63250cd1e3233 |
| Source note | uspto-grants-2005_03 |