HCID 16228413, compound → HCID 10291517, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 1-(pyridine-4-carbonyl)pyrrolidine-2-carboxylic acid (example 19A, b; 60%, 1.5 g, 4.1 mmol), ethyl 2-bromo-3-(4-fluorophenyl)propenoate (example 19A, c; 1.0 g, 4 mmol) and acetic anhydride (10 ml) are heated under reflux for 21 h in an oil bath maintained at a temperature of 150° C. After cooling and concentrating in vacuo (Rotavapor), needles deposit. The concentrated crystal suspension is treated with ether/ethyl acetate (1:2) and the crystals are filtered off with suction. The mother liquor is completely concentrated and the residue is purified by cc (Al2O3— ether/THF 9:1):

Provenance & Evidence