2-(6-fluoro-1H-indol-3-yl)acetamide → 3-(4,4-dimethyl-5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-4-(6-fluoro-1H-indol-3-yl)pyrrole-2,5-dione

HRID 983976Notes

Reaction equation

HRID 983976 reaction equation
[F:1][C:2]1[CH:10]=[C:9]2[C:5]([C:6]([CH2:11][C:12]([NH2:14])=[O:13])=[CH:7][NH:8]2)=[CH:4][CH:3]=1.C[O:16][C:17](=O)[C:18]([C:20]1[C:30]2=[C:31]3[C:26](=[CH:27][CH:28]=[CH:29]2)[CH2:25][CH2:24][C:23]([CH3:33])([CH3:32])[N:22]3[CH:21]=1)=O>>[CH3:32][C:23]1([CH3:33])[CH2:24][CH2:25][C:26]2[C:31]3=[C:30]([C:20]([C:18]4[C:17](=[O:16])[NH:14][C:12](=[O:13])[C:11]=4[C:6]4[C:5]5[C:9](=[CH:10][C:2]([F:1])=[CH:3][CH:4]=5)[NH:8][CH:7]=4)=[CH:21][N:22]13)[CH:29]=[CH:28][CH:27]=2

Participants

3

Reactant 2

HCID 219500622-(6-fluoro-1H-indol-3-yl)acetamideHCID 69742930(4,4-dimethyl-5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)oxo-acetic acid methyl ester

Product 1

HCID 225568033-(4,4-dimethyl-5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-4-(6-fluoro-1H-indol-3-yl)pyrrole-2,5-dione

Procedure

Beginning with (6-fluoroindol-3-yl)acetamide and (4,4-dimethyl-5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)oxoacetic acid methyl ester, the title compound was prepared essentially as described in Example 1.

Sources & evidence

ORD record
ord-53f1bbccab224aedab1592bdf3dfa63c
Source dataset
uspto-grants-2005_03
Patent number
US06867198B2

Reaction notes

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