2-(4-fluoro-1H-indol-3-yl)acetamide → 3-(6,6-dimethyl-8-fluoro-5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-4-(4-fluoro-1H-indol-3-yl)pyrrole-2,5-dione

HRID 983978Notes

Reaction equation

HRID 983978 reaction equation
[F:1][C:2]1[CH:10]=[CH:9][CH:8]=[C:7]2[C:3]=1[C:4]([CH2:11][C:12]([NH2:14])=[O:13])=[CH:5][NH:6]2.C[O:16][C:17](=O)[C:18]([C:20]1[C:30]2=[C:31]3[C:26](=[CH:27][C:28]([F:32])=[CH:29]2)[C:25]([CH3:34])([CH3:33])[CH2:24][CH2:23][N:22]3[CH:21]=1)=O>>[CH3:33][C:25]1([CH3:34])[C:26]2[C:31]3=[C:30]([C:20]([C:18]4[C:17](=[O:16])[NH:14][C:12](=[O:13])[C:11]=4[C:4]4[C:3]5[C:7](=[CH:8][CH:9]=[CH:10][C:2]=5[F:1])[NH:6][CH:5]=4)=[CH:21][N:22]3[CH2:23][CH2:24]1)[CH:29]=[C:28]([F:32])[CH:27]=2

Participants

3

Reactant 2

HCID 219500362-(4-fluoro-1H-indol-3-yl)acetamideHCID 69743463(6,6-dimethyl-8-fluoro-5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)oxoacetic acid methyl ester

Product 1

HCID 225567543-(6,6-dimethyl-8-fluoro-5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-4-(4-fluoro-1H-indol-3-yl)pyrrole-2,5-dione

Procedure

Beginning with (4-fluoroindol-3-yl)acetamide and (6,6-dimethyl-8-fluoro-5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)oxoacetic acid methyl ester, the title compound was prepared essentially as described in Example 1.

Sources & evidence

ORD record
ord-5d7c9505e65045b7a3391c2eb32f5105
Source dataset
uspto-grants-2005_03
Patent number
US06867198B2

Reaction notes

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