2-(6-Methoxy-1H-indol-3-yl)acetamide → 3-(6,6-dimethyl-8-fluoro-5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-4-(6-methoxy-1H-indol-3-yl)pyrrole-2,5-dione

HRID 983980Notes

Reaction equation

HRID 983980 reaction equation
[CH3:1][O:2][C:3]1[CH:11]=[C:10]2[C:6]([C:7]([CH2:12][C:13]([NH2:15])=[O:14])=[CH:8][NH:9]2)=[CH:5][CH:4]=1.C[O:17][C:18](=O)[C:19]([C:21]1[C:31]2=[C:32]3[C:27](=[CH:28][C:29]([F:33])=[CH:30]2)[C:26]([CH3:35])([CH3:34])[CH2:25][CH2:24][N:23]3[CH:22]=1)=O>>[CH3:34][C:26]1([CH3:35])[C:27]2[C:32]3=[C:31]([C:21]([C:19]4[C:18](=[O:17])[NH:15][C:13](=[O:14])[C:12]=4[C:7]4[C:6]5[C:10](=[CH:11][C:3]([O:2][CH3:1])=[CH:4][CH:5]=5)[NH:9][CH:8]=4)=[CH:22][N:23]3[CH2:24][CH2:25]1)[CH:30]=[C:29]([F:33])[CH:28]=2

Participants

3

Reactant 2

HCID 178925962-(6-Methoxy-1H-indol-3-yl)acetamideHCID 69743463(6,6-dimethyl-8-fluoro-5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)oxoacetic acid methyl ester

Product 1

HCID 225567273-(6,6-dimethyl-8-fluoro-5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-4-(6-methoxy-1H-indol-3-yl)pyrrole-2,5-dione

Procedure

Beginning with (6-methoxyindol-3-yl)acetamide and (6,6-dimethyl-8-fluoro-5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)oxoacetic acid methyl ester, the title compound was prepared essentially as described in Example 1.

Sources & evidence

ORD record
ord-2a7a84ba2ea9447fac2adc51353a07c0
Source dataset
uspto-grants-2005_03
Patent number
US06867198B2

Reaction notes

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